Thermo Fisher Scientific Tankyrase 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299, HeLa, HepG2
• Predicted reactivity: Mouse (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379).
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, key components of the beta-catenin destruction complex. Poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation.
Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
Mediates poly-ADP-ribosylation of TERF1, contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
[UniProt]

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-28069_Tankyrase_2_Q9H2K2-1_Rabbit.svg, PA5-28069_Tankyrase_2_Q9H2K2-1_Rabbit_PDP.jpeg)