Thermo Fisher Scientific NAGA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
WLAWERFRCN INCDEDPKNC ISEQLFMEMA DRMAQDGWRD MGYTYLNIDD CWIGGRDASG RLMPDPKRFP HGIPFLADYV HSLGLKLGIY ADMGNFTCMG YPGTTLDKVV QDAQTFAEWK VDMLKLDGCF ST

Highest antigen sequence identity to the following orthologs:

• Mouse: 88%
• Rat: 88%

Target Information

NAGA (N-acetylgalactosaminidase, alpha), also known as alpha-galactosidase B or GALB, is a 411 amino acid lysosomal protein belonging to the glycosyl hydrolase 27 family. It may exist as a homodimer and plays a critical role in glycolipid breakdown.
NAGA encodes alpha-N-acetylgalactosaminidase, a lysosomal enzyme that cleaves alpha-N-acetylgalactosaminyl groups from glycoconjugates. Mapping to human chromosome 22q13.2, NAGA defects are the cause of an autosomal recessive disorder with three phenotypes, known as Schindler disease (types I, II, and III) or NAGA deficiency (types I, II, and III).
Schindler disease type I is the most severe form, followed by type III (mild-to-moderate), and type II (Kanzaki disease) characterized by mild intellectual impairment and angiokeratoma corporis diffusum.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.