Thermo Fisher Scientific NAGA Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NAGA. Recombinant protein control fragment (Product #RP-91478). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NAGA,uniProtId:P17050-1,ncbiNodeId:9606,antigenRange:30-161,antigenLength:411,antigenImageFileName:PA5-51433_NAGA_P17050-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51433_NAGA_P17050-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644438

Product Specific Information

Immunogen sequence: WLAWERFRCN INCDEDPKNC ISEQLFMEMA DRMAQDGWRD MGYTYLNIDD CWIGGRDASG RLMPDPKRFP HGIPFLADYV HSLGLKLGIY ADMGNFTCMG YPGTTLDKVV QDAQTFAEWK VDMLKLDGCF ST

Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.

Target Information

NAGA (N-acetylgalactosaminidase, alpha), also known as alpha-galactosidase B or GALB, is a 411 lysosomal protein belonging to the glycosyl hydrolase 27 family that may exist as a homodimer and plays a critical role in glycolipid breakdown. NAGA encodes alpha-N-acetylgalactosaminidase, a lysosomal enzyme, which cleaves alpha-N-acetylgalactosaminyl groups from glycoconjugates. Mapping to human chromosome 22q13. 2, NAGA defects are the cause of an autosomal recessive disorder with three phenotypes, known as Schindler disease (types I, II and III) or NAGA deficiency (types I, II and III). Characterized by neurologic manifestations that range in severity, Schindler disease type I is the most severe form, followed by type III, which may have mild-to-moderate effects. Schindler disease type II, also known as Kanzaki disease, is characterized by mild intellectual impairment and angiokeratoma corporis diffusum.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.