Thermo Fisher Scientific ErbB3 Monoclonal Antibody (SP71)
ErbB3 단백질을 검출하기 위한 Rabbit 모노클로날 항체로, IHC 및 Flow Cytometry에 사용 가능. Human 종에 반응하며 비결합형 액상 형태로 제공. Protein A/G 정제, 항원 회복 시 citrate buffer 사용 권장. 연구용으로만 사용.
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Thermo Fisher Scientific ErbB3 Monoclonal Antibody (SP71)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SP71 |
| Immunogen | Synthetic peptide corresponding to internal region of human c-erbB3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.048 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.6, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537868 |
Product Specific Information
Heat-mediated antigen retrieval is recommended prior to staining, using a 10 mM citrate buffer (pH 6.0) for 10 minutes followed by cooling at room temperature for 20 minutes.
After antigen retrieval, incubate samples with primary antibody for 30 minutes at room temperature.
A suggested positive control tissue is small intestine.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors that binds to ligands in the heregulin family.
ErbB3 is over-expressed in various tumors such as those of the prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on chromosome 12q13 and encodes a transmembrane receptor tyrosine kinase (~160/180 kDa).
ErbB3 forms heterodimers with other EGF receptor family members, leading to activation of pathways involved in cell proliferation and differentiation.
Alternative splicing produces different isoforms, including a secreted form that modulates the activity of the membrane-bound receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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