Thermo Fisher Scientific LOX Monoclonal Antibody (OTI5C4), TrueMAB
LOX 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 사람, 개, 랫트 반응성. 동결건조 형태, PBS 버퍼에 8% 트레할로스 포함. 세포외기질 형성과 암 전이에 관련된 LOX 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–168 of human LOX produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase that catalyzes the oxidation of primary amines to reactive aldehydes.
It plays a crucial role in the formation and repair of the extracellular matrix and is involved in developmental regulation, tumor suppression, cell motility, and cellular senescence.
The secreted form of LOX contributes to the invasive properties of hypoxic cancer cells, making it an important therapeutic target for metastasis prevention and treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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