Thermo Fisher Scientific ALK Monoclonal Antibody (OTI19H9), TrueMAB
인간 ALK 단백질(aa 1300–1620)에 특이적인 Mouse monoclonal antibody. Western blot에 1:2,000 희석으로 사용 가능. Lyophilized 형태로 제공되며, PBS(pH 7.3, 8% trehalose) 버퍼에 보관. 뇌 발달 및 종양 연구용으로 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI19H9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene have been identified in several tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement often leads to a fusion gene combining the ALK gene (chromosome 2) and the nucleophosmin (NPM) gene (chromosome 5), producing the oncogenic NPM-ALK fusion protein.
ALK is a receptor protein-tyrosine kinase with a putative transmembrane and extracellular domain, showing the greatest sequence similarity to LTK.
It plays an important role in neuronal development and signaling within the nervous system.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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