Thermo Fisher Scientific MICA/B Monoclonal Antibody (6D4), FITC
인간 MICA/B 단백질을 인식하는 마우스 단클론 항체로, FITC 형광 표지되어 있습니다. NK 세포 및 세포독성 T세포의 CD314(NKG2D) 활성 차단 연구에 적합합니다. 유세포분석(Flow Cytometry)에 사용 가능하며, 4°C 암소 보관이 권장됩니다.
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Applications
- Flow Cytometry (Flow): 2–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D4 |
| Immunogen | Transfected C1R cells expressing MICA |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898639 |
Available Formats
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- Biotin
- PE-Cyanine7
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes a common extracellular epitope on MICA and MICB glycoproteins, which are transmembrane ligands of CD314 (NKG2D). It can block CD314-mediated activation of NK cells and cytotoxic T cells.
Target Information
MICA encodes the highly polymorphic MHC (HLA) class I chain-related gene A. The protein is expressed on the cell surface but does not associate with beta-2-microglobulin like canonical class I molecules. MICA functions as a stress-induced antigen recognized by intestinal epithelial gamma delta T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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