Thermo Fisher Scientific TNFRSF18 Monoclonal Antibody (UMAB203), UltraMAB
TNFRSF18(GITR) 단백질을 인식하는 UMAB203 단클론 항체로, 인간 시료에 반응합니다. IHC, ICC/IF, ChIP 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 액상 형태로 안정적이며, -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
| ChIP assay (ChIP) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB203 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 26–162 of human TNFRSF18 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene in humans, located at 1p36.33. This gene encodes a member of the TNF receptor superfamily. The receptor shows increased expression upon T-cell activation and plays a key role in immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice indicate its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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