Thermo Fisher Scientific Phospho-RSK Pan (Ser221, Ser227, Ser218, Ser232) Polyclonal Antibody
RSK1/2/3/4의 Ser221, Ser227, Ser218, Ser232 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 ICC/IF에 적합하며, 인간, 마우스, 랫트 반응성. PBS+50% glycerol에 보관, -20°C에서 안정적. 연구용으로만 사용.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RPS6KA1 (Accession Q15418), corresponding to amino acid residues around phosphorylated Ser221. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899274 |
Product Specific Information
This antibody detects endogenous levels of RSK1/2/3/4 only when phosphorylated at Ser221/227/S218/232.
Target Information
The p90 ribosomal S6 kinases (RSKs) are a family of serine/threonine kinases functioning at the terminus of the ERK pathway. In humans, this family includes four isoforms (RSK1–RSK4). Each member contains two distinct, catalytically functional kinase domains activated sequentially by phosphorylation. RSK regulates gene expression by phosphorylating transcriptional regulators such as c-Fos, estrogen receptor, NFκB/IκBα, and CREB. ERK activation leads to phosphorylation of the C-terminal kinase of RSK, which subsequently activates the N-terminal kinase. RSKs are found in both cytoplasm and nucleus, and upon activation, cytosolic RSK translocates to the nucleus to phosphorylate and activate transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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