Thermo Fisher Scientific Phospho-POLR2A (Thr4) Polyclonal Antibody
Rpb1 CTD의 Thr4 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot에 적합하며, 비결합형 액상 형태로 제공됩니다. PBS와 50% 글리세롤에 보관하며, -20°C에서 안정적으로 저장 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Rpb1 CTD around the phosphorylation site of Thr4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899272 |
Product Specific Information
This antibody detects endogenous levels of Rpb1 CTD only when phosphorylated at Thr4.
Target Information
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) is a DNA-dependent RNA polymerase that catalyzes transcription of DNA into RNA using ribonucleoside triphosphates as substrates.
POLR2A is the largest subunit and a catalytic component of RNA polymerase II, responsible for synthesizing mRNA precursors and many functional non-coding RNAs.
It forms the polymerase active center with the second largest subunit and plays a central role in the basal transcription machinery.
RPB1 contributes to the core element with the central cleft and clamp structures that interact with DNA during transcription.
Phosphorylation of the C-terminal domain (CTD) of RPB1 regulates transcription initiation, elongation, termination, and mRNA processing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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