Thermo Fisher Scientific Phospho-RB1 (Ser788) Polyclonal Antibody
RB1 단백질의 Ser788 인산화 형태를 특이적으로 인식하는 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 고순도 정제 및 안정한 액상 형태로 제공되며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RB1 (Accession P06400), corresponding to amino acid residues around phosphorylated Ser788 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899269 |
Product Specific Information
Antibody detects endogenous levels of Retinoblastoma (Rb) only when phosphorylated at Ser788.
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues, but not on tyrosine. It forms complexes with SV40 large T antigen, adenovirus E1A, and HPV-16 E. Rb protein regulates transcription, and loss of its function leads to uncontrolled cell growth. Mutations in the RB gene are associated with various cancers, including breast, colon, prostate, kidney, nasopharyngeal carcinoma, and leukemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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