Thermo Fisher Scientific LIME Monoclonal Antibody (LIME-06)
LIME-06 단클론 항체로 인간 LIME 단백질(aa 141-295)에 특이적 결합. Flow Cytometry 및 Immunoprecipitation에 사용 가능. Protein A로 정제된 액상 형태, 1 mg/mL 농도. T세포 신호전달 연구용으로 적합.
- 판매단위
- pk
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 8–12 µg/mL
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LIME-06 |
| Immunogen | Bacterially expressed intracellular fragment corresponding to aa 141–295 of human LIME |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076495 |
Product Specific Information
The antibody LIME-06 was raised against an intracellular fragment corresponding to amino acids 141–295 of human LIME, a 30 kDa Lck-interacting transmembrane adaptor expressed by T cells.
Target Information
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with an unusually basic cytoplasmic domain, expressed by T cells. Upon ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases, as well as their negative regulator Csk.
Csk-mediated phosphorylation of the C-terminal negative-regulatory tyrosine of LIME-associated Lck can increase enzymatic activity compared with the total Lck pool, making LIME a positive regulator of TCR-dependent T cell signaling. Under certain conditions, LIME may also mediate inhibitory signals.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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