Thermo Fisher Scientific LIME Monoclonal Antibody (LIME-10)
LIME 단백질의 세포질 도메인을 인식하는 마우스 단클론 항체로, Western blot, IHC, Flow Cytometry에 사용 가능. T 세포 신호전달 연구용. Protein A 정제, 액상 형태, 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LIME-10 |
| Immunogen | COOH-terminal peptide comprising residues 281-296 of the human LIME conjugated to keyhole limpet hemocyanin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076497 |
Product Specific Information
This antibody reacts with the cytoplasmic domain of LIME, a 30 kDa Lck-interacting transmembrane adaptor expressed by T cells.
Western blotting: Reducing conditions recommended.
Target Information
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with an unusually basic cytoplasmic domain, expressed by T cells. Upon ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck, Fyn, and the negative regulator Csk.
Csk-mediated phosphorylation of the C-terminal negative-regulatory tyrosine of LIME-associated Lck can increase enzymatic activity compared to the total Lck pool. Thus, LIME serves as a positive regulator of TCR-dependent T cell signaling, though it may mediate inhibitory signals under certain conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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