Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134), PE
SCN10A 단백질을 인식하는 S134 클론의 단일클론 항체로 PE 형광 표지됨. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 마우스, 설치류 등 반응성 보유. 4°C 보관, 단백질 G 정제, 1 mg/mL 농도.
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Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134), PE
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S134 |
| Immunogen | Fusion protein amino acids 1724–1956 of rat Nav1.8 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931926 |
Available Formats
- Unconjugated (MA5-27663)
- APC (MA5-45469)
- FITC (MA5-45470)
- PerCP (MA5-45471)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45472 detects Nav1.8 in 10 µg COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as secondary antibody.
Detects approximately 220 kDa. No cross-reactivity against other Nav channels.
Target Information
Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. It mediates voltage-dependent sodium ion permeability in excitable membranes and is involved in neuropathic pain mechanisms.
Members of the Deg/ENaC superfamily share structural similarity, possessing short intracellular termini, two membrane-spanning segments, and a large extracellular loop with conserved cysteine-rich regions.
ENaC isoforms (α, β, γ) are essential for sodium and fluid balance in kidney, lung, and colon, and regulate blood pressure via aldosterone-dependent sodium reabsorption.
Mutations in ENaC subunits lead to disorders such as Liddle’s syndrome and pseudohypoaldosteronism (PHA-1).
Diseases associated with SCN10A include Episodic Pain Syndrome, Familial, 2 and Sodium Channelopathy-Related Small Fiber Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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