Thermo Fisher Scientific CYP3A4/CYP3A5 Monoclonal Antibody (F24 P2 B10)
CYP3A4/CYP3A5 단백질을 인식하는 Mouse monoclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 및 소 시료에 반응하며, 약물 대사 관련 연구에 유용합니다. -20°C 보관, sodium azide 함유.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F24 P2 B10 |
| Immunogen | Synthetic peptide corresponding to residues E S R D G T V S G A, conjugated to ovalbumin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2261518 |
Product Specific Information
MA3-032 detects Cytochrome P450 3A4/3A5 from human cell line HepG2, and from bovine liver and pancreas samples.
It has been successfully used in Western blot applications, detecting a ~54 kDa band representing Cytochrome P450 3A4/3A5.
The immunogen is a synthetic peptide corresponding to residues E S R D G T V S G A, conjugated to ovalbumin.
Target Information
CYP3A5 is a member of the cytochrome P450 superfamily of enzymes.
These monooxygenases catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
CYP3A5 localizes to the endoplasmic reticulum, and its expression is induced by glucocorticoids and some pharmacological agents.
The enzyme metabolizes drugs such as nifedipine and cyclosporine, as well as steroid hormones including testosterone, progesterone, and androstenedione.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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