Thermo Fisher Scientific Cdc37 Monoclonal Antibody (C1)
Cdc37 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(C1). Western blot, IHC, ICC/IF, Flow cytometry, IP 등 다양한 응용에 적합. Rat, Hamster, Human, Mouse에서 반응하며, HSP90 관련 단백질 복합체 연구에 유용. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 8 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:200 | – |
| Flow Cytometry (Flow) | 1:50 | – |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat, Hamster, Human, Mouse |
| Published Species | Fruit fly, Human, Mouse, Rabbit, Yeast |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C1 |
| Immunogen | Purified mouse Cdc37 fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2077740 |
Product Specific Information
MA3-029 detects Cdc37 from hamster, human, mouse, and rat cells and tissues.
It has been successfully used in Western blot, FACS, immunofluorescence, immunocytochemistry, and immunoprecipitation (under denaturing conditions).
- In Western blot, this antibody recognizes a single 50 kDa protein representing Cdc37 in HeLa cell extract.
- Immunofluorescence staining of Cdc37 in Hepa1 cells with MA3-029 shows mostly cytoplasmic staining concentrated around the nuclear membrane.
- Weak non-specific bands may appear in Jurkat, A431, and NIH-3T3 cell lysates.
The MA3-029 antigen is purified mouse Cdc37 fusion protein.
Target Information
In S. cerevisiae, Cdc37 is a key regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs).
Cdc37 is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
HSP90 has been shown to interact with many of the same cellular targets as Cdc37. Cdc37 (also known as p50) forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck, Fgr), Raf, and pp60v-src.
Cdc37 functions as a chaperone both independently and in concert with HSP90, and is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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