Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1/3045)

Applications

Product Specifications

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also found as a soluble plasma protein.

Fibronectin consists of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays a critical role in cell adhesion and migration processes such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis.

Fibronectin expression is elevated in non-small cell lung carcinoma, enhancing tumorigenicity and resistance to chemotherapy-induced apoptosis. The fibronectin gene undergoes alternative splicing, potentially generating up to 20 transcript variants, though the full-length nature of some remains undetermined.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.