Thermo Fisher Scientific Zap-70 Polyclonal Antibody
Rabbit polyclonal antibody targeting the C-terminal region of human ZAP-70. Validated for Western blot applications. Recommended for detecting ZAP70 in T-cells and NK cells. Supplied as a liquid, unconjugated form with 1 mg/mL concentration. Store at 4...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Bacterially expressed fusion protein representing the C-terminal 160 amino acids of human ZAP-70 with a histidine tag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1088340 |
Product Specific Information
This antibody recognizes the C-terminal region of human ZAP70 protein tyrosine kinase (intracellular antigen).
ZAP70 is susceptible to degradation; therefore, it is recommended to use freshly prepared cell lysates with protease inhibitors to avoid non-specific staining of degradation products.
Western Blot: Reducing conditions are recommended.
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase belonging to the Syk family. It is expressed exclusively in T-cells and natural killer (NK) cells and is essential for T-cell receptor (TCR) activation.
Upon TCR engagement, ZAP70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region between the SH2 and kinase domains.
- Phosphorylation of tyrosines 315 (Vav binding site) and 319 (Lck binding site) enhances ZAP70-mediated lymphocyte signaling.
- Phosphorylation of tyrosine 292 attenuates ZAP70 activation and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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