Thermo Fisher Scientific Kinesin 5B Polyclonal Antibody
Kinesin 5B 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunocytochemistry에 적합. 인간, 마우스, 돼지 시료 반응. Affinity chromatography로 정제된 1 mg/mL 액상 제품. 4°C 보관, 동결 금지.
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Applications
- Western Blot (WB): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Stalk domain of human kinesin (aa 331–906), expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2132394 |
Product Specific Information
This antibody detects total levels of endogenous kinesin protein (intracellular antigen).
Target Information
Kinesin 5B is a microtubule-dependent motor protein required for normal distribution of mitochondria and lysosomes. It can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. It regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle, in a BICD2-dependent manner, it antagonizes dynein function and drives the separation of nuclei and centrosomes. Kinesin 5B is also required for anterograde axonal transport of MAPK8IP3/JIP3, which is essential for axon elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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