Thermo Fisher Scientific S1PR3 (EDG3) (extracellular) Polyclonal Antibody, FITC

Applications

• Flow Cytometry (Flow): Tested dilution 5 µg

Product Specifications

Product Specific Information

Reconstitution: Add 50 µL double distilled water (DDW) depending on the sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
The reconstituted solution can be stored at 4°C, protected from light, for up to 1 week.
For longer storage, aliquot and keep at -20°C. Avoid multiple freeze/thaw cycles.
Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

EDG-3 (S1PR3) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids.
The ligand for EDG-3 is sphingosine-1-phosphate. There are eight known members of the EDG receptor family, involved in growth-related processes such as cellular proliferation, differentiation, survival, and suppression of apoptosis.
They also mediate cytoskeletal responses like contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated, differ in tissue distribution, and couple to multiple G proteins to signal through Ras/MAP kinase, Rho, phospholipase C, and protein tyrosine kinases.
EDG-3 is expressed in cardiovascular, leukocyte-containing, and other tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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