Thermo Fisher Scientific SATB2 Recombinant Rabbit Monoclonal Antibody (SATB2, 4374R)
Human SATB2 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체로, IHC(P)에서 1–2 µg/mL로 사용 가능. HEK293 세포에서 발현된 IgG 형 항체이며, Protein A/G 정제, PBS buffer에 보존. 연구용으로 핵 내 DNA 결합 단백질 SATB2 검출에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SATB2, 4374R |
| Immunogen | Synthetic peptide corresponding to residues within aa200–300 of human SATB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 min.
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions.
It recognizes the sugar-phosphate structure of double-stranded DNA and acts as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and inducing local chromatin-loop remodeling.
SATB2 also serves as a docking site for chromatin remodeling enzymes, recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers.
It plays a key role in the development of upper-layer neurons and regulation of corticocortical connections in the cerebral cortex.
Mutations in SATB2 are associated with isolated cleft palate (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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