Thermo Fisher Scientific SATB2 Recombinant Rabbit Monoclonal Antibody (SATB2, 4374R)

Thermo Fisher Scientific SATB2 Recombinant Rabbit Monoclonal Antibody (SATB2, 4374R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

• For PFA-fixed tissues: incubate antibody for 30 minutes at room temperature.
• For formalin-fixed tissues: heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.

Target Information

SATB2 is a DNA-binding protein that associates with nuclear matrix or scaffold regions and recognizes the sugar-phosphate backbone of double-stranded DNA. It functions as a transcription factor regulating gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling. SATB2 acts as a docking site for chromatin remodeling enzymes, recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers. It plays a crucial role in cortical neuron differentiation by modulating BCL11B expression, repressing Ctip2, and regulating corticocortical connections. Mutations in SATB2 are associated with cleft palate isolated (CPI).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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