Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Recombinant Rabbit Monoclonal Antibody (SATB2/8697R)
SATB2 단백질을 표적으로 하는 대장암 마커용 재조합 토끼 단일클론 항체. 인간 시료에 반응하며, IHC(P) 및 IHC(PFA) 적용 가능. 고순도 Protein A/G 정제, PBS buffer 제공. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SATB2/8697R |
| Immunogen | Synthetic peptide corresponding to residues within aa200–300 of human SATB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
SATB2 acts as a transcription factor regulating nuclear gene expression by binding to matrix attachment regions (MARs) and inducing local chromatin-loop remodeling.
It serves as a docking site for chromatin remodeling enzymes, recruiting HDACs (corepressors) or HATs (coactivators) to promoters and enhancers.
SATB2 is essential for initiating upper-layer neuron (UL1) specific genetic programs and repressing deep-layer neuron (DL) and UL2 genes, likely via modulation of BCL11B expression.
Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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