Thermo Fisher Scientific FBXW7 Monoclonal Antibody (OTI6F5), TrueMAB
FBXW7 단백질을 인식하는 Mouse 단일클론 항체로, Western blot 및 IHC(P)에서 검증됨. Human 시료 반응성. 1 mg/mL 농도의 액상 형태로 제공되며, PBS/BSA/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–354 of human FBXW7 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family characterized by an approximately 40 amino acid F-box motif. These proteins form part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination.
F-box proteins are categorized into three classes:
- Fbws: containing WD-40 domains
- Fbls: containing leucine-rich repeats
- Fbxs: containing various interaction modules or no recognizable motifs
FBXW7 (also known as FBX30) belongs to the Fbws class and includes seven tandem WD40 repeats. It binds directly to cyclin E and is thought to target cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 have been identified in ovarian and breast cancer cell lines, suggesting a potential role in tumorigenesis. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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