Thermo Fisher Scientific IGF2R Recombinant Rabbit Monoclonal Antibody (ARC0263)
IGF2R 단백질을 인식하는 재조합 토끼 단클론 항체. Western blot, ICC/IF, ELISA에 적합. 인간, 마우스, 랫트 반응성. HEK293 세포에서 발현, Affinity Chromatography로 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0263 |
| Immunogen | Synthetic peptide corresponding to amino acids 2392–2491 of human Cation-independent M6PR (IGF2R, NP_0008673) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849301 |
Product Specific Information
Immunogen sequence:
TTKSVKALSS LHGDDQDSED EVLTIPEVKV HSGRGAGAES SHPVRNAQSN ALQEREDDRV GLVRGEKARK GKSSSAQQKT VSSTKLVSFH DDSDEDLLHI
Target Information
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are transported within the cell via two interconnected cycles mediated by approximately 300 kDa cation-independent mannose 6-phosphate receptors (CI-MPR).
The biosynthetic cycle involves MPR transport of newly synthesized lysosomal enzymes from the trans-Golgi network to late endosomes or early lysosomes. The endocytic cycle carries extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes.
MPRs cycle between these compartments every 3 hours, with most localized in late endosomes, fewer in the trans-Golgi network, and about 10% at the cell surface.
In addition to man6P binding, MPR contains a separate site for type II insulin-like growth factor (IGF-II) and can bind both ligands simultaneously. A soluble ~240 kDa truncated form representing the extracellular domain is found circulating in serum and retains ligand-binding capability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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