Thermo Fisher Scientific GTF2IRD/TFII-IRD1 Polyclonal Antibody
GTF2IRD/TFII-IRD1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. Human 시료에 반응하며, FFPE 조직에서는 citrate buffer pH 6.0 전처리 권장.
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Applications and Tested Dilution
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 650 and 700 of human general transcription factor 2I repeat domain containing 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Williams-Beuren syndrome (WBS) is a developmental disorder caused by a hemizygous microdeletion on chromosome 7q11.23. It is an autosomal dominant condition characterized by physical, cognitive, and behavioral traits such as facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies, and neurological abnormalities.
The WBSCR11 gene (also known as GRF2IRD1, GTF3, Cream1, MusTRD1 in human, and BEN in mouse) is located within the WBS deletion region and may contribute to developmental symptoms due to the loss of this transcription factor. WBSCR11 is expressed in all adult tissues as several variants and shows discrete spatial and temporal expression during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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