Thermo Fisher Scientific SPRED1 Polyclonal Antibody
SPRED1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC에 적합합니다. 인간, 마우스, 랫트에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 신경세포 분화 및 종양 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | – |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Hamster, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 20 amino acid peptide near the center of the human Spred1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155784 |
Product Specific Information
- A suggested positive control is mouse brain tissue lysate.
- PA5-20617 can be used with blocking peptide PEP-0737.
Target Information
The Ras–MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins.
Spred1 acts by suppressing the phosphorylation and activation of Raf.
The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis.
Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC.
Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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