Thermo Fisher Scientific CUEDC2 Polyclonal Antibody
CUEDC2 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal 항체로, WB 및 ICC/IF에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide from near the carboxy terminus of human CUEDC2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156017 |
Product Specific Information
- Suggested positive control: HeLa cell lysate
- PA5-20620 can be used with blocking peptide PEP-0740
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.
CUEDC2 (CUE domain-containing protein 2) was identified through yeast two-hybrid screening as a protein interacting with the progesterone receptor (PR) and promoting progesterone-induced PR degradation via the ubiquitin-proteasome pathway.
CUEDC2 also decreases the sumoylation of PR and interacts with IKK-alpha and IKK-beta to reduce NF-kappa-B activation by decreasing IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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