Thermo Fisher Scientific IL-28A Monoclonal Antibody (7B9A4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-31779 has been tested in indirect ELISA.

Target Information

IL-28A belongs to the IFN lambda family, a novel family of cytokines within the IL-10 superfamily. The three members of this family are IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), collectively known as type III interferons.
The IFN lambdas signal through a heterodimeric receptor composed of IL-10R2 and IFN lambda R1 (IL-28R alpha). Signaling occurs via the Jak/STAT pathway, similar to type I IFNs (IFN alpha/beta), and activates many of the same genes despite low sequence homology.
Both IFN families display antiviral activity through induction of antiviral proteins and upregulation of MHC class I expression. They also exhibit antiproliferative and antitumor effects, suggesting potential as alternatives to IFN alpha in cancer therapy.
Unlike type I IFNs, which act broadly, IFN lambda responses are limited to dendritic and certain tumor cells due to restricted expression of IFN lambda R1. IFN lambda stimulation can also drive dendritic cells to produce CD4⁺CD25⁺FoxP3⁺ regulatory T cells, indicating a possible immunoregulatory role.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.