Thermo Fisher Scientific IL-28A Monoclonal Antibody (6H9E6)
인간 IL-28A 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot, ICC/IF, ELISA에 적합하며, Protein G로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6H9E6 |
| Immunogen | Purified recombinant fragment of human IL28A (AA: 1–200) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787403 |
Product Specific Information
MA5-31780 has been tested in indirect ELISA.
Target Information
IL-28A belongs to the IFN lambda family, a novel group of cytokines within the IL-10 superfamily. This family includes IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), collectively known as type III interferons.
These cytokines signal through a heterodimeric receptor composed of IL-10R2 (shared with other IL-10 family members) and IFN lambda R1 (IL-28R alpha), which is unique to the IFN lambda family. Signaling occurs via the Jak/STAT pathway, similar to type I interferons (IFN alpha/beta), activating many of the same genes despite low sequence homology.
Both IFN families exhibit antiviral activity by inducing antiviral proteins and upregulating MHC class I expression. They also have antiproliferative and antitumor properties, suggesting potential in cancer therapy. Unlike type I IFNs, IFN lambda responses are limited to dendritic and some tumor cells due to restricted IFN lambda R1 expression. IFN lambda stimulation can also promote the generation of CD4⁺CD25⁺FoxP3⁺ regulatory T cells, indicating an immunoregulatory function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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