Thermo Fisher Scientific IL-28A Monoclonal Antibody (6H9E6)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-31780 has been tested in indirect ELISA.

Target Information

IL-28A belongs to the IFN lambda family, a novel group of cytokines within the IL-10 superfamily. This family includes IL-29 (IFN lambda 1), IL-28A (IFN lambda 2), and IL-28B (IFN lambda 3), collectively known as type III interferons.

These cytokines signal through a heterodimeric receptor composed of IL-10R2 (shared with other IL-10 family members) and IFN lambda R1 (IL-28R alpha), which is unique to the IFN lambda family. Signaling occurs via the Jak/STAT pathway, similar to type I interferons (IFN alpha/beta), activating many of the same genes despite low sequence homology.

Both IFN families exhibit antiviral activity by inducing antiviral proteins and upregulating MHC class I expression. They also have antiproliferative and antitumor properties, suggesting potential in cancer therapy. Unlike type I IFNs, IFN lambda responses are limited to dendritic and some tumor cells due to restricted IFN lambda R1 expression. IFN lambda stimulation can also promote the generation of CD4⁺CD25⁺FoxP3⁺ regulatory T cells, indicating an immunoregulatory function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.