Thermo Fisher Scientific IL-1 alpha Recombinant Superclonal Antibody (1HCLC)

Applications

• Western Blot (WB): 4–5 µg/mL

Product Specifications

Product Specific Information

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific.
They consist of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
These antibodies recognize multiple epitopes, providing higher detection sensitivity for low-abundance targets.
Each lot is produced with a known mixture of light and heavy chains, minimizing biological variability.

Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The physical product and performance remain unchanged.

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells.
Encoded by the IL1A gene on chromosome 2q13, it signals through IL-1RI and IL-1RII receptors shared with IL-1 beta.
IL-1 alpha triggers the production of other proinflammatory cytokines and initiates acute-phase responses in target cells.
Its activity is moderated by IL-1 Receptor Antagonist (IL-1RA), which blocks receptor binding competitively.

IL-1 alpha regulates NF-kappaB and MAPK activities, stimulates IL6 and COX-2 expression, and enhances nitric oxide (NO) production.
Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.