Thermo Fisher Scientific IL-4 Recombinant Polyclonal Antibody (1HCLC)
Recombinant rabbit polyclonal antibody recognizing human IL-4. Combines polyclonal sensitivity with monoclonal specificity. Suitable for Western blot at 4–5 µg/mL. Provides consistent lot-to-lot reproducibility. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 4–5 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 1HCLC |
| Immunogen | Protein corresponding to amino acids 25–153 of human IL-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Wet or Dry ice (international) |
| RRID | AB_2532535 |
Product Specific Information
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies, and ensuring consistent performance through recombinant production.
These antibodies recognize multiple epitope sites on the target, enhancing detection sensitivity for low abundance targets, while maintaining reproducibility across lots by eliminating biological variability.
Target Information
Interleukin-4 (IL-4) is a pleiotropic immune-modulatory cytokine produced by activated T cells and acts as a ligand for the interleukin-4 receptor. IL-4 exhibits a broad range of biological actions. The IL-4 receptor also binds IL-13, contributing to overlapping cytokine functions.
STAT6 plays a crucial role in mediating IL-4–dependent immune regulatory signaling. The IL-4 gene is part of a cytokine cluster on chromosome 5q, along with IL-3, IL-5, IL-13, and CSF2. IL-4 and IL-13 genes are located in close proximity and are co-regulated by long-range regulatory elements spanning approximately 120 kilobases. IL-4 delta 2 is a known splice variant of IL-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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