Thermo Fisher Scientific CD80 Monoclonal Antibody (7D3)
CD80 (B7-1) 단백질을 표적하는 Mouse IgG2a 단클론 항체로, Western blot 및 ELISA에 적합. 인간 시료 반응성, 액상 형태로 제공되며 PBS buffer에 보관. 연구용으로 T세포 활성화 관련 연구에 활용 가능.
- 카탈로그번호
- H00000941-M05
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7D3 |
| Immunogen | CD80 (AAH11399.2, 137–230 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SVKADFPTPS ISDFEIPTSN IRRIICSTSG GFPEPHLSWL ENGEELNAIN TTVSQDPETE LYAVSSKLDF NMTTNHSFMC LIKYGHLRVN QTFN
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T-cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152).
Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T-cell activation.
CD80 is rapidly induced on the surface of activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, follicular B lymphoma cells, T cells, and monocytes.
The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes through binding to CD28 and CTLA4 ligands.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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