Thermo Fisher Scientific CD80 Monoclonal Antibody (5F5)
Thermo Fisher Scientific CD80 Monoclonal Antibody (5F5)은 인간 CD80(B7-1) 단백질을 인식하는 Mouse IgG1 항체입니다. Western blot과 ELISA에 사용 가능하며, 액상 형태로 제공됩니다. PBS buffer에 보존되며 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1–5 µg/mL
- ELISA: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5F5 |
| Immunogen | CD80 (AAH11399.2, 137 a.a. ~230 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SVKADFPTPS ISDFEIPTSN IRRIICSTSG GFPEPHLSWL ENGEELNAIN TTVSQDPETE LYAVSSKLDF NMTTNHSFMC LIKYGHLRVN QTFN
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T-cell costimulatory molecule CD28 and inhibitory receptor CTLA-4 (CD152).
Both are expressed on professional antigen-presenting cells and are essential for T-cell activation.
CD80 is rapidly induced on activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, follicular B lymphoma cells, T cells, and monocytes.
The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes via CD28 and CTLA4 binding.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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