Thermo Fisher Scientific CD80 Monoclonal Antibody (7E6)
CD80 단백질을 인식하는 Mouse IgG1 단클론 항체로, 인간 시료에 반응합니다. Western blot과 ELISA에 적합하며, PBS buffer 기반 액상 형태로 제공됩니다. 연구용으로만 사용되며, T세포 활성화 관련 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7E6 |
| Immunogen | CD80 (AAH11399.2, 137–230 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SVKADFPTPS ISDFEIPTSN IRRIICSTSG GFPEPHLSWL ENGEELNAIN TTVSQDPETE LYAVSSKLDF NMTTNHSFMC LIKYGHLRVN QTFN
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the critical T cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both molecules are expressed on professional antigen-presenting cells and are essential for T cell activation. CD80 is rapidly induced on activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes.
The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes via binding to CD28 and CTLA4 ligands.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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