Thermo Fisher Scientific CD28 Monoclonal Antibody (1D7)
CD28 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, 인간 시료에서 Western blot과 ELISA에 사용 가능. 비결합형 액상 형태로 제공되며, PBS buffer에 보존제 없이 저장. T세포 활성화 연구용으로 적합.
- 카탈로그번호
- H00000940-M21
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D7 |
| Immunogen | CD28 (NP_006130.1, aa 18–152) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GNKILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKP
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T-cell specific surface glycoprotein. It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes. CD28 provides the essential costimulatory signal for T-cell activation by binding CD80 and CD86 on antigen-presenting cells. It prevents T-cell anergy and premature apoptosis. In mice, CD28 is expressed on all CD4+ and CD8+ T cells in peripheral lymphoid organs and blood, with varying expression levels during thymocyte maturation.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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