Thermo Fisher Scientific CD28 Monoclonal Antibody (4B5)
인간 CD28 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB 및 ELISA에 적합합니다. 친화 크로마토그래피로 정제되었으며 PBS(pH 7.4)에 보관됩니다. T세포 활성화 및 공동자극 연구에 유용한 연구용 항체입니다.
- 카탈로그번호
- H00000940-M22
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B5 |
| Immunogen | CD28 (NP_006130.1, 18–152 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GNKILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKP
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes.
CD28 serves as a critical T cell costimulatory receptor by binding CD80 and CD86 on antigen-presenting cells, providing the essential second activation signal.
It prevents T cells from entering an anergic or apoptotic state and is expressed in both CD4+ and CD8+ T cells in peripheral tissues and blood.
In the thymus, CD28 expression is highest on immature T cells and decreases in mature thymocytes.
Dysfunction of CD28 is associated with diseases such as mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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