Thermo Fisher Scientific CD35/CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody (CR1/6380)
인간 CD35/CR1 단백질을 인식하는 마우스 단클론 항체로, 여포성 수지상세포(FDC) 마커로 사용됩니다. IHC(P)에서 1–2 µg/mL 농도로 사용 가능하며, 단백질 A/G로 정제된 액상 형태입니다. CD35는 보체 수용체로 면역 복합체 처리 및 보체 활성 억제에 관여합니다.
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Thermo Fisher Scientific CD35/CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody (CR1/6380)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CR1/6380 |
| Immunogen | Recombinant fragment (within aa650–850) of human CD35 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody stability: 24 months
- Positive Control: Follicular dendritic cells (FDC) in tonsil
- Cellular Localization: Cell surface
- Specificity Comments:
CD35 (complement receptor 1) is a cell membrane-bound glycoprotein expressed on erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. It acts as a receptor for C3b and C4b, key components of the complement system, aiding in the clearance of foreign macromolecules. CD35 is a mature B-cell marker labeling follicular dendritic reticulum cells and related tumors such as follicular dendritic cell sarcoma.
Target Information
CD35 (CR1, Complement Receptor 1) is a monomeric glycoprotein serving as a receptor for C3b and C4b. It mediates binding to complement-activated particles and immune complexes. CD35 exists in four allotypes (C: 160 kDa, A: 190 kDa, B: 220 kDa, D: 250 kDa) and is involved in immune complex processing, phagocytosis of C3b complexes, and inhibition of complement activation.
It is expressed on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, and follicular dendritic cells, but negative on basophils.
Reduced CD35 expression or gene mutations are associated with gallbladder carcinoma, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, and sarcoidosis. Mutations may confer protection against severe malaria by reducing Plasmodium falciparum rosetting.
Alternate splice variants and a secreted form of CD35 have been reported but not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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