Thermo Fisher Scientific CPS1/Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Monoclonal Antibody (SPM615)
CPS1 단백질을 인식하는 단클론 항체로 간세포 표지자 연구에 적합함. IHC 및 ICC/IF 등 다양한 응용 가능. 인간 및 개 시료 반응성 확인됨. 고순도 Protein A/G 정제, 보존제 무첨가 PBS 용액 형태.
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Thermo Fisher Scientific CPS1/Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Monoclonal Antibody (SPM615)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM615 |
| Immunogen | Recombinant human CPS1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The mitochondrial enzyme encoded by this gene catalyzes the synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction represents the first committed step of the urea cycle, crucial for removing excess urea from cells. The encoded protein may also function as a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been identified for this gene, with the shortest isoform possibly not localized to the mitochondrion. Mutations in this gene are associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and venoocclusive disease following bone marrow transplantation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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