Thermo Fisher Scientific DISC1 Polyclonal Antibody, DyLight 550
DISC1 단백질을 표적하는 DyLight 550 결합 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. 면역조직화학 및 면역세포화학 실험에 적합하며, 형광 최대치 556/570 nm로 안정적인 신호를 제공합니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 보장합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 2.5–5 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to internal region (residues 400–500) of rat DISC1 protein |
| Conjugate | DyLight™ 550 |
| Excitation / Emission Max | 556 / 570 nm |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 50 mM sodium borate |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153752 |
Product Specific Information
- Theoretical molecular weight of DISC1: ~90 kDa
- Alternative splicing may produce bands at ~75 and ~100 kDa
- Suggested positive control: human brain sections (neurons and glia)
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein interacting with centrosomal and cytoskeletal components. It plays key roles in neuronal migration, neurite architecture, and intracellular transport. DISC1 is expressed in regions such as the hippocampus, cerebral cortex, cerebellum, and hypothalamus.
Mutations or translocations in the DISC1 gene are linked to schizophrenia. The protein contains both globular N-terminal and helical C-terminal domains, enabling interactions with proteins like MIPT3, MAP1A, NUDEL, alpha-actinin 2, beta 4-spectrin, ATF-4, and ATF-5.
Reduced DISC1 expression can lead to abnormal neuronal integration and dendritic development, suggesting its importance in synapse formation and neuronal morphology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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