Thermo Fisher Scientific BMI-1 Polyclonal Antibody, Biotin
Thermo Fisher Scientific의 BMI-1 Polyclonal Antibody, Biotin은 인간 및 생쥐 시료에 반응하는 Rabbit IgG 기반 항체입니다. Western blot 및 면역세포염색에 사용되며, Biotin으로 결합되어 검출이 용이합니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an internal region (residues 1–100) of human Bmi1 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1.09 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154451 |
Product Specific Information
- Suggested positive control: Human and mouse skeletal muscle.
Target Information
Bmi1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, which maintains the transcriptionally repressive state of numerous developmental genes, including Hox genes. The PRC1 complex acts through chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A at Lys-119, leading to heritable changes in chromatin expressibility. Within the complex, Bmi1 is essential for stimulating the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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