Thermo Fisher Scientific Human IL-31 Synthetic Peptide
Human IL-31 중심부 18개 아미노산 서열로 구성된 합성 펩타이드. PA5-20220 항체의 블로킹 펩타이드로 사용 가능. 액상 형태, 1 mg/mL 농도, PBS 버퍼(0.1% BSA 포함) 내 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human IL-31.
PEP-0333 can be used as a blocking peptide with polyclonal antibody PA5-20220.
Target Information
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. Overexpression of IL-31 in transgenic mice results in pruritis, alopecia, and skin lesions, and in humans may cause atopic dermatitis, suggesting IL-31 as a potential target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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