Thermo Fisher Scientific Mouse IL-31 Synthetic Peptide
Mouse IL-31 아미노 말단 16개 서열에 해당하는 합성 펩타이드로, PA5-20219 항체의 블로킹 펩타이드로 사용 가능. 마우스 IL-31 관련 연구용으로 적합하며, 액상 형태로 PBS 버퍼 내 안정적 보관 가능. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of mouse IL31.
PEP-0332 can be used as a blocking peptide with polyclonal antibody PA5-20219.
Target Information
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor.
In response to IL-31 binding, these proteins activate the JAK/STAT and AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells.
Overexpression of IL-31 in transgenic mice leads to pruritis, alopecia, and skin lesions; in humans, it may contribute to atopic dermatitis, suggesting IL-31 as a potential target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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