Thermo Fisher Scientific PSMA Monoclonal Antibody (GCP-05), PE
인간 PSMA를 인식하는 단클론 항체로, PE 형광표지되어 유세포분석에 적합합니다. 암세포 및 신경계 조직에서 PSMA 발현 연구에 활용됩니다. 4°C 암조건 보관, 동결 금지. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific PSMA Monoclonal Antibody (GCP-05), PE
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GCP-05 |
| Immunogen | Amino acids 44–750 of human GCPII |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152630 |
Additional Formats
- Unconjugated (Cat. MA1-10335)
- Alexa Fluor 488 (Cat. MA5-18161)
- Custom conjugation available upon request
Product Specific Information
This antibody recognizes the extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95–110 kDa transmembrane glycoprotein expressed mainly in tumor neovasculatures, nervous system, and jejunum. It is an important prostate tumor marker.
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein functions as a glutamate carboxypeptidase on substrates such as folate and N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues including prostate, central and peripheral nervous system, and kidney. Mutations may lead to impaired folate absorption and hyperhomocysteinemia. In the brain, expression may relate to glutamate excitotoxicity, while in the prostate, it is up-regulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer. Alternative splicing produces multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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