Thermo Fisher Scientific PSMA Monoclonal Antibody (GCP-05), PE

Thermo Fisher Scientific PSMA Monoclonal Antibody (GCP-05), PE

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µg/mL

Product Specifications

Additional Formats

• Unconjugated (Cat. MA1-10335)
• Alexa Fluor 488 (Cat. MA5-18161)
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes the extracellular domain (preferentially in native form) of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95–110 kDa transmembrane glycoprotein expressed mainly in tumor neovasculatures, nervous system, and jejunum. It is an important prostate tumor marker.

Target Information

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein functions as a glutamate carboxypeptidase on substrates such as folate and N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues including prostate, central and peripheral nervous system, and kidney. Mutations may lead to impaired folate absorption and hyperhomocysteinemia. In the brain, expression may relate to glutamate excitotoxicity, while in the prostate, it is up-regulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer. Alternative splicing produces multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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