Thermo Fisher Scientific Phospho-EGFR (Tyr1173) Monoclonal Antibody (EM-13)
인간 EGFR의 Tyr1173 인산화 부위를 인식하는 단클론 항체로, Western blot, Flow cytometry, Immunoprecipitation에 사용 가능. Protein A로 정제된 액상 항체이며, 4°C에서 보관. 다양한 종양 연구에 활용되는 연구용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-13 |
| Immunogen | Synthetic phospho-peptide covering sequence around tyrosine 1173 of human EGFR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152744 |
Product Specific Information
This antibody reacts with human EGFR (ErbB1 / HER1) phosphorylated on intracellular tyrosine 1173.
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression of EGFR has been linked to numerous types of cancer and is the target of both biological and small molecule therapeutics.
EGFR is encoded by the EGFR gene located on chromosome 7 in humans and belongs to the HER/ErbB family of proteins, which includes ERbB2, ERbB3, and ERbB4.
Upon ligand binding (e.g., EGF or TGF-α), EGFR undergoes dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and in squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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