Thermo Fisher Scientific Phospho-EGFR (Tyr992) Monoclonal Antibody (EM-12)
인간 EGFR(Tyr992) 인산화 부위에 특이적으로 결합하는 단일클론 항체. Western blot, Flow cytometry, Immunoprecipitation에 사용 가능. Protein A 정제, 1 mg/mL 농도의 액상 형태. 4°C 보관, 동결 금지.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-12 |
| Immunogen | Synthetic phospho-peptide covering sequence around tyrosine 992 of human EGFR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156610 |
Product Specific Information
This antibody reacts with human EGFR (ErbB1 / HER1) phosphorylated on intracellular tyrosine 992.
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous cancer types, and EGFR is the target of both biological and small molecule therapeutics.
The EGFR gene is located on chromosome 7 in humans and belongs to the HER/ErbB family, which includes ERbB2, ERbB3, and ERbB4. EGFR is a transmembrane receptor; ligand binding (e.g., EGF, TGF-α) induces dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and in squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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