Thermo Fisher Scientific Granzyme B Monoclonal Antibody (CLB-GB11)
Granzyme B를 인식하는 단클론 항체로, 인간 및 비인간 영장류에 반응합니다. Flow Cytometry에 적합하며, Protein A로 정제된 액상 형태입니다. 세포독성 T세포와 NK세포 내 Granzyme B 검출 연구에 활용됩니다.
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Thermo Fisher Scientific Granzyme B Monoclonal Antibody (CLB-GB11)
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–4 µg/mL
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLB-GB11 |
| Immunogen | Human NK cell line YT-INDY-derived Granzyme B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 8.0 |
| Contains | 15 mM Sodium Azide |
| Storage Conditions | 4°C, Do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_11154492 |
Product Specific Information
This antibody recognizes granzyme B, a 31 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
Target Information
Granzyme B is a member of the granzyme serine protease family, found in granules of cytotoxic T cells and NK cells. It is also known as CGL1 (cathepsin G-like-1) and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1). Granzyme B plays a crucial role in inducing apoptosis of target cells via caspase activation and mitochondrial pathways. It interacts with the mannose 6-phosphate receptor, functioning as a death receptor during cytotoxic T cell-induced apoptosis. Granzymes are neutral serine proteases stored in specialized lytic granules of CTLs and NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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