Thermo Fisher Scientific ATP7B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

- -

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500

-

Immunocytochemistry (ICC/IF)

2-10 ug/mL

-

Immunoprecipitation (IP)

Assay-Dependent

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide made to an internal sequence nearer the N-terminus of human ATP7b. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ATP7B,uniProtId:P35670-1,ncbiNodeId:9606,antigenRange:1,antigenLength:1465,antigenImageFileName:PA1-16583_ATP7B_P35670-1_Rabbit.svg,antigenImageFileNamePDP:PA1-16583_ATP7B_P35670-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_2062837

Product Specific Information

Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Suggested positive control: HuH7 hepatocarcinoma cell extracts, antigen standard for ATP7B (transient overexpression lysate).

Target Information

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.