Thermo Fisher Scientific Desmoglein-3 Monoclonal Antibody (DSG3, 2839)
Desmoglein-3 단백질을 표적하는 마우스 모노클로널 항체로 인간 시료에 반응합니다. IHC(P) 및 Peptide Array에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 세포 간 결합 연구 및 pemphigus vulgaris 관련 연구용으로 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DSG3, 2839 |
| Immunogen | Recombinant fragment (around aa 379–491) human DSG3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is part of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including skin, oral mucosa, and esophagus.
Desmoglein 3 is characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies leads to loss of cell-cell adhesion, clinically manifesting as blisters on skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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