Thermo Fisher Scientific Desmoglein-3 Monoclonal Antibody (DSG3, 2839)
Desmoglein-3 단백질을 표적하는 mouse monoclonal antibody로, 인간 시료에 반응합니다. IHC(P) 및 peptide array에 사용 가능하며, 고순도 Protein A/G 정제 제품입니다. 피부 및 점막 조직 연구용으로 적합합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DSG3, 2839 |
| Immunogen | Recombinant fragment (around aa 379–491) of human DSG3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a desmosomal cadherin family protein crucial for cell-cell adhesion.
It is predominantly expressed in stratified squamous epithelium such as skin, oral mucosa, and esophagus.
Dsg3 is the autoantigen of pemphigus vulgaris (PV), an autoimmune disease characterized by blister formation due to loss of cell-cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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