Thermo Fisher Scientific TCIRG1 Polyclonal Antibody
TCIRG1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody입니다. Western blot에 적합하며 인간, 마우스, 랫트 시료에 반응합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다.
- 카탈로그번호
- PA534419
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid synthetic peptide near the amino terminus of human TCIRG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551771 |
Product Specific Information
- Suggested positive control: EL4 cell lysate
- PA5-34419 can be used with blocking peptide PEP-1461.
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in luminal acidification of these organelles.
Genetic defects in TCIRG1 cause a severe form of autosomal recessive osteopetrosis, characterized by increased bone density, decreased bone strength, and inflammation in bone tissues.
TCIRG1 is also required for normal insulin secretion and macrophage-mediated bacterial killing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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